Zofran, Ondansetron antiemetic means, antagonist serotonin receptors. Thanks to the newest researches it is revealed that Zofran, Ondansetron can reduce displays of a syndrome of cancellation opioids.После revealings of the fact of participation serotonin (5-HT3) receptors in pathogenesis opioids dependences, the group of the Californian scientists has shown efficiency agonist 5-HT3 receptors zofran, in reduction of expressiveness of symptoms of cancellation opioids in experiment on rodents and in clinical research at people..
Results of research are published in online magazine «Pharmacogenetics and Genomics» on February, 17th, 2009 by group of researchers under the direction of J. Devid Klark. Scientists entered to mice within 4 days escalating doses morphin, then appointed naloxon, and considered, how many time animals jumped up within 15 minutes that is expression of physical dependence. Further were exposed euthanasia, and were investigated DNA from samples of a brain. It was spent genetic mapping and identification of the genes connected with a susceptibility to dependence from opioids. It is found out that gene 5-HT3, corresponding serotonin receptor type 5-HT3 was the leader gene-candidate. In the further experiments appointment selective antagonist 5-HT3 receptors Ondansetron considerably reduced naloxon-induced jumps at mice with dependence from morphin, and dose-related..
Researchers specify that «simultaneous appointment Ondansetron with each dose morphin during 4 day formations of dependence, reduced naloxon-mediated the answer to cancellation morphin». Then scientists have conducted research in which eight healthy volunteers of a male, before intravenous introduction morphin with the subsequent naloxon, have preliminary received medical treatment placebo or Ondansetron 8 mg. At seven of eight examinees cancellation symptoms opioids were observed.
It is shown that the given preparation possessed a wide spectrum of action, reducing all physically observable 12 symptoms of cancellation opioids. Scientists believe that «therapy 5-HT3 antagonists can solve a part of the problems connected with application opioids in medicine».